Change is the holly grail of enterprise success. Neuro-surgery, being on the forefront of scientific research in this century offers a great concept to borrow in change management. Neuroplasticity. It is the function of brain change between, short, longer and permanent adaption to learning. This is the way we decided to move forward in change management strategy. The three applications we evidenced, “chemo-synthesis”, “structural” and “functional” we can help every organization move forward in a world which changes at a ten times higher pace than twenty years ago.